MCM4

Across TCGA patient cohorts, MCM4 protein abundance is significantly associated with the RNA expression of many other genes, with 20,478 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MCM4-associated genes across cancer lineages are CENPM, MCM5, and GINS1. Each is linked with MCM4 in more than 9 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCM4 versus CENPM in UCEC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPM →	+1.162	+0.478	<.001	<.001	3	10
UCEC	MCM5 →	+0.951	+0.433	<.001	<.001	3	10
LUAD	GINS1 →	+1.406	+0.978	<.001	<.001	3	10
LUAD	CENPI →	+1.405	+0.989	<.001	<.001	3	10
OV	OIP5 →	+1.069	+0.902	<.001	<.001	3	10
UCEC	ASF1B →	+1.351	+0.679	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,478 associations by consensus.

MCM4 vs CENPM — UCEC

Explore this scatter interactively →