MCM4

Across TCGA patient cohorts, MCM4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM4-associated genes across cancer lineages are TFRC, 4E-BP1, and Ku80. Each is linked with MCM4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MCM4-low versus MCM4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.435	+2.000	.011	.029	3	3
UCEC	4E-BP1 →	+0.224	+1.936	.010	.008	3	3
UCEC	Ku80 →	+0.187	+1.472	.014	.007	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.364	-1.702	.012	.003	3	2
UCEC	C-Raf →	+0.107	+1.222	.021	.035	3	2
UCEC	Di-Ras3 →	-0.128	-1.716	.007	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

TFRC by MCM4 expression — UCEC

Explore this box plot interactively →