MCM4

Across TCGA cell cohorts, MCM4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,441 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCM4-associated GO terms across cancer lineages are Cell cycle DNA replication, Mitotic spindle midzone assembly, and DNA replication. Each is linked with MCM4 in more than 18 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cell cycle DNA replication grouped by MCM4-low versus MCM4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cell cycle DNA replication →	+0.227	+2.084	<.001	<.001	3	19
SOFT_TISSUE	Mitotic spindle midzone assembly →	+0.314	+1.582	<.001	<.001	3	19
BONE	DNA replication →	+0.153	+2.040	<.001	<.001	3	19
BONE	DNA-templated DNA replication →	+0.175	+2.197	<.001	<.001	3	19
BONE	DNA replication initiation →	+0.230	+1.958	<.001	.001	3	19
OESOPHAGUS	DNA strand elongation involved in DNA replication →	+0.228	+1.617	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,441 associations by consensus.

Cell cycle DNA replication by MCM4 expression — BONE

Explore this box plot interactively →