MCM4

Across TCGA cell cohorts, MCM4 mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM4-associated genes across cancer lineages are CP466722, 50869, and 776928. Each is linked with MCM4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM4-to-partner and partner-to-MCM4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CP466722 grouped by MCM4-low versus MCM4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM4→partner) and Y-score (partner→MCM4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CP466722 →	+0.391	+2.652	.048	.045	3	1
LARGE_INTESTINE	50869 →	+0.433	+2.649	.041	.046	3	1
LARGE_INTESTINE	776928 →	+0.647	+2.649	.041	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.707	+2.652	.030	.045	3	1
LARGE_INTESTINE	WZ3105 →	+0.698	+2.652	.044	.045	3	1
LARGE_INTESTINE	Quizartinib →	+0.388	+2.652	.015	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CP466722 by MCM4 expression — LARGE_INTESTINE

Explore this box plot interactively →