MCM3AP

Across TCGA pan-cancer cohorts, MCM3AP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated MCM3AP data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MCM3AP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MCM3AP expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where MCM3AP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.861	0.323	.001	11	view →
UCEC	OS	Quartile	All	0.891	1.000	.029	6	view →
HNSC	DFS	Median	All	0.696	0.837	.032	5	view →
OV	DFS	Median	All	1.000	0.693	.032	4	view →
GBM	OS	Tertile	All	0.540	0.311	.027	4	view →
LUAD	DFS	Median	All	0.926	0.905	.024	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

MCM3AP–PDAC (OS)

Open the PDAC breakdown →