MCM3AP

Across TCGA patient cohorts, MCM3AP mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM3AP-associated genes across cancer lineages are CD49b, Smac, and Dvl3. Each is linked with MCM3AP in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM3AP-to-partner and partner-to-MCM3AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD49b grouped by MCM3AP-low versus MCM3AP-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3AP→partner) and Y-score (partner→MCM3AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	CD49b →	+0.399	+3.000	.011	.036	3	3
COAD	Smac →	-0.267	-3.798	.011	<.001	3	3
SKCM	Dvl3 →	-0.271	-3.000	.006	.035	3	3
UCEC	Caspase-7-cleavedD198 →	+0.482	+1.315	<.001	.005	3	3
UCEC	Caveolin-1 →	-0.392	-1.514	.028	.012	3	3
UCEC	cIAP →	+0.081	+1.066	.016	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

CD49b by MCM3AP expression — STAD

Explore this box plot interactively →