MCM3AP

Across TCGA cell cohorts, MCM3AP mutation is significantly associated with the RNA expression of many other genes, with 596 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCM3AP-associated genes across cancer lineages are ASB17, HFE, and SH3GL2. Each is linked with MCM3AP in more than 1 cancer types. Because this analysis shows association rather than direction, both MCM3AP-to-partner and partner-to-MCM3AP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by MCM3AP-low versus MCM3AP-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM3AP→partner) and Y-score (partner→MCM3AP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	2
LARGE_INTESTINE	HFE →	+0.757	+2.502	.006	.005	3	2
LARGE_INTESTINE	SH3GL2 →	+1.506	+3.837	<.001	<.001	3	2
LARGE_INTESTINE	CUEDC2 →	+0.565	+2.502	.002	.005	3	2
LARGE_INTESTINE	CCDC47 →	+0.619	+3.321	<.001	.002	3	2
LARGE_INTESTINE	RPA2 →	+0.582	+3.459	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 596 associations by consensus.

ASB17 by MCM3AP expression — OVARY

Explore this box plot interactively →