MCM3

Across TCGA pan-cancer cohorts, MCM3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated MCM3 data layer compared with 24 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MCM3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated MCM3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where MCM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	III,IV	0.890	1.000	.029	36	view →
HNSC	DFS	Median	All	0.623	1.000	.003	30	view →
PDAC	OS	Median	II,III,IV	0.663	0.988	<.001	29	view →
LUAD	OS	Tertile	All	0.588	1.000	.001	18	view →
GBM	OS	Quartile	All	0.807	1.000	.005	6	view →
LSCC	DFS	Tertile	II,III,IV	0.856	0.537	.021	6	view →
UCEC	DFS	Median	III,IV	0.904	0.445	.037	4	view →
CCRCC	OS	Tertile	All	0.655	1.000	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

MCM3–COAD (DFS)

Open the COAD breakdown →