MCM10

Across TCGA patient cohorts, MCM10 mutation is significantly associated with the RNA expression of many other genes, with 3,654 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCM10-associated genes across cancer lineages are MIR6737, NDUFAB1, and UQCRH. Each is linked with MCM10 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCM10-to-partner and partner-to-MCM10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6737 grouped by MCM10-low versus MCM10-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCM10→partner) and Y-score (partner→MCM10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6737 →	+0.477	+5.506	<.001	.005	3	3
UCEC	NDUFAB1 →	+0.384	+3.855	.005	<.001	3	3
COAD	UQCRH →	+0.672	+3.241	<.001	.008	3	3
UCEC	TIMM44 →	+0.395	+2.169	<.001	<.001	3	3
READ	WDR7-OT1 →	+0.168	+5.653	<.001	.003	3	2
BRCA	OR10AA1P →	+0.046	+5.800	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,654 associations by consensus.

MIR6737 by MCM10 expression — BRCA

Explore this box plot interactively →