MCL1

Across TCGA patient cohorts, MCL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,918 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MCL1-associated proteins across cancer lineages are ZYX_S344, ZFP36_S60, and TIMM8A. Each is linked with MCL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCL1 versus ZYX_S344 in OV, with a Pearson correlation of 0.35.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZYX_S344 →	+0.710	+0.448	.009	.001	2	8
BRCA	ZFP36_S60 →	+0.892	+0.642	<.001	.002	3	7
COAD	TIMM8A →	-0.468	-0.633	<.001	<.001	3	6
BRCA	NDUFAB1 →	-0.409	-0.452	<.001	<.001	3	6
LSCC	PIK3C2A_S259 →	+0.575	+0.452	<.001	<.001	3	6
HNSC	UBAP1_S146 →	+0.605	+0.545	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,918 associations by consensus.

MCL1 vs ZYX_S344 — OV

Explore this scatter interactively →