MCL1

Across TCGA patient cohorts, MCL1 protein abundance is significantly associated with the RNA expression of many other genes, with 7,982 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MCL1-associated genes across cancer lineages are CXCL9, AXIN2, and EXO1. Each is linked with MCL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MCL1 versus CXCL9 in UCEC, with a Pearson correlation of 0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCL9 →	+1.831	+0.364	<.001	<.001	3	3
COAD	AXIN2 →	-0.865	-0.321	.001	<.001	3	3
COAD	EXO1 →	+0.678	+0.337	<.001	.004	3	3
GBM	MTURN →	-1.335	-0.313	<.001	.001	3	3
BRCA	SNRNP70 →	-0.698	-0.297	<.001	.003	3	3
BRCA	GARNL3 →	-0.586	-0.298	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,982 associations by consensus.

MCL1 vs CXCL9 — UCEC

Explore this scatter interactively →