MCL1

Across TCGA patient cohorts, MCL1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCL1-associated genes across cancer lineages are eEF2, p70-S6K, and PDCD4. Each is linked with MCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MCL1-low versus MCL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.437	+3.169	.026	.020	3	1
UCEC	p70-S6K →	+0.247	+2.827	.019	.035	3	1
UCEC	PDCD4 →	-0.664	-3.169	.010	.020	3	1
UCEC	N-Ras →	-0.129	-3.156	.047	.020	2	1
UCEC	PRAS40_pT246 →	+0.289	+3.183	.002	.010	1	2
UCEC	FoxM1 →	+0.303	+3.169	.032	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

eEF2 by MCL1 expression — UCEC

Explore this box plot interactively →