MCL1

Across TCGA cell cohorts, MCL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,109 significant associations in total. BONE shows the largest number of these associations.

The most reproducible MCL1-associated GO terms across cancer lineages are Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, mRNA destabilization, and Regulation of translational initiation. Each is linked with MCL1 in more than 13 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway grouped by MCL1-low versus MCL1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.212	+1.014	<.001	<.001	3	14
BLOOD_Lymphoma	mRNA destabilization →	+0.056	+0.990	.002	.004	3	13
STOMACH	Regulation of translational initiation →	+0.093	+1.311	<.001	<.001	3	13
STOMACH	Positive regulation of TORC2 signaling →	+0.111	+0.770	.006	.002	2	14
PANCREAS	Cytosolic transport →	+0.048	+0.820	.001	<.001	3	13
URINARY_TRACT	RNA destabilization →	+0.065	+1.175	.002	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,109 associations by consensus.

Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway by MCL1 expression — BONE

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