MCL1

Across TCGA cell cohorts, MCL1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MCL1-associated genes across cancer lineages are SMIM23, OR5AN1, and DEFB124. Each is linked with MCL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MCL1-to-partner and partner-to-MCL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SMIM23 grouped by MCL1-low versus MCL1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCL1→partner) and Y-score (partner→MCL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SMIM23 →	+0.640	+4.887	<.001	.009	3	2
BLOOD_Lymphoma	OR5AN1 →	+0.042	+4.350	<.001	.005	3	1
BLOOD_Lymphoma	DEFB124 →	+0.165	+4.927	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

SMIM23 by MCL1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →