MCF2

Across TCGA cell cohorts, MCF2 mutation is significantly associated with the mutation status of many other genes, with 6,563 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MCF2-associated genes across cancer lineages are SPTBN1, ACAN, and SLC12A1. Each is linked with MCF2 in more than 5 cancer types. Because this analysis shows association rather than direction, both MCF2-to-partner and partner-to-MCF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPTBN1 grouped by MCF2-low versus MCF2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCF2→partner) and Y-score (partner→MCF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SPTBN1 →	+3.510	+3.807	.004	.004	1	6
SOFT_TISSUE	ACAN →	+3.066	+4.369	.005	.005	1	6
LUNG_NSCLC_LUAD	SLC12A1 →	+3.604	+2.718	.003	.003	1	6
BREAST	RP1 →	+3.189	+4.557	.001	.001	1	6
LUNG_NSCLC_LUAD	CARD11 →	+2.604	+2.421	.004	.004	1	6
SKIN	COL6A6 →	+2.089	+2.647	.002	.002	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,563 associations by consensus.

SPTBN1 by MCF2 expression — BREAST

Explore this box plot interactively →