MCCC1

Across TCGA patient cohorts, MCCC1 mutation is significantly associated with the RNA expression of many other genes, with 4,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MCCC1-associated genes across cancer lineages are RNA5SP489, MIA-RAB4B, and RNU6-1205P. Each is linked with MCCC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both MCCC1-to-partner and partner-to-MCCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP489 grouped by MCCC1-low versus MCCC1-high in LGG.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCCC1→partner) and Y-score (partner→MCCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	RNA5SP489 →	+0.473	+7.977	<.001	.007	3	3
UCEC	MIA-RAB4B →	+0.087	+2.055	<.001	<.001	3	2
BLCA	RNU6-1205P →	+0.348	+3.396	.004	.006	3	2
UCEC	SNX3P1Y →	+0.058	+3.671	<.001	.008	3	2
LUSC	ARPP19P2 →	+0.250	+3.507	<.001	.005	3	2
UCEC	GPR143 →	-0.577	-3.668	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,115 associations by consensus.

RNA5SP489 by MCCC1 expression — LGG

Explore this box plot interactively →