MCC

Across TCGA cell cohorts, MCC mutation is significantly associated with the RNA expression of many other genes, with 86 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MCC-associated genes across cancer lineages are OXT, OTOS, and MAGEB4. Each is linked with MCC in more than 1 cancer types. Because this analysis shows association rather than direction, both MCC-to-partner and partner-to-MCC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OXT grouped by MCC-low versus MCC-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MCC→partner) and Y-score (partner→MCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	OXT →	+0.107	+4.169	<.001	.008	3	2
LUNG_NSCLC_LUAD	OTOS →	+0.063	+3.106	<.001	.009	3	2
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
BLOOD_Lymphoma	MBL2 →	+0.076	+3.606	<.001	.002	3	2
SKIN	HMHB1 →	+0.076	+6.022	<.001	.001	3	2
BONE	CPN1 →	+0.029	+4.000	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

OXT by MCC expression — BONE

Explore this box plot interactively →