MC5R

Across TCGA patient cohorts, MC5R RNA expression is significantly associated with the RNA expression of many other genes, with 12,166 significant associations in total. ACC shows the largest number of these associations.

The most reproducible MC5R-associated genes across cancer lineages are MC2R, RTL6, and PLXNA4. Each is linked with MC5R in more than 19 cancer types. Because this analysis shows association rather than direction, both MC5R-to-partner and partner-to-MC5R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MC5R versus MC2R in ACC, with a Pearson correlation of 0.51.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC5R→partner) and Y-score (partner→MC5R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	MC2R →	+3.042	+0.230	<.001	<.001	3	20
ACC	RTL6 →	+1.126	+0.186	<.001	<.001	2	18
SARC	PLXNA4 →	+0.925	+0.222	<.001	<.001	3	17
ACC	ABI2 →	+0.888	+0.376	<.001	<.001	3	16
THYM	BMPR2 →	+0.758	+1.053	<.001	<.001	3	15
THYM	USP51 →	+0.730	+0.850	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,166 associations by consensus.

MC5R vs MC2R — ACC

Explore this scatter interactively →