MC5R

Across TCGA pan-cancer cohorts, MC5R RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated MC5R data layer compared with 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher MC5R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MC5R expression acts as an unfavorable survival marker, although some lineages such as LUAD and TGCT show a favorable association.

COAD, ACC, and STAD are the cancer types where MC5R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	0.322	0.577	<.001	87	view →
ACC	DFS	Median	All	0.416	0.748	<.001	83	view →
STAD	OS	Median	All	0.509	0.649	.005	74	view →
UVM	OS	Tertile	All	0.578	0.976	<.001	38	view →
MESO	OS	Quartile	IV	0.265	0.724	.001	31	view →
LIHC	OS	Tertile	All	0.608	0.791	.004	30	view →
CHOL	OS	Tertile	All	0.538	0.782	.015	27	view →
KIRC	OS	Tertile	All	0.484	0.691	.001	24	view →
LAML	DFS	Tertile	All	0.263	0.539	.007	18	view →
UCEC	DFS	Tertile	All	0.773	0.855	.021	18	view →
LUAD	DFS	Tertile	All	0.874	0.754	.007	17	view →
LUSC	DFS	Tertile	III,IV	0.148	0.827	<.001	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

MC5R–COAD (DFS)

Open the COAD breakdown →