MC5R

Across TCGA patient cohorts, MC5R mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC5R-associated genes across cancer lineages are JNK2, Notch1, and p62 Lck ligand. Each is linked with MC5R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC5R-to-partner and partner-to-MC5R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by MC5R-low versus MC5R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC5R→partner) and Y-score (partner→MC5R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.164	+1.710	.021	.025	3	2
UCEC	Notch1 →	+0.182	+1.925	<.001	.005	3	2
UCEC	p62 Lck ligand →	+0.266	+1.817	.023	.015	3	2
UCEC	S6_pS240_S244 →	+0.395	+2.183	.006	.033	3	2
UCEC	Caspase-7-cleavedD198 →	+0.604	+1.720	.004	.025	3	2
UCEC	Caspase-8 →	-0.261	-2.973	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

JNK2 by MC5R expression — UCEC

Explore this box plot interactively →