MC5R

Across TCGA cell cohorts, MC5R mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MC5R-associated genes across cancer lineages are PLA2G3, MAGEB4, and NFATC1. Each is linked with MC5R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC5R-to-partner and partner-to-MC5R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLA2G3 grouped by MC5R-low versus MC5R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC5R→partner) and Y-score (partner→MC5R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLA2G3 →	+1.143	+3.215	<.001	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	1
LARGE_INTESTINE	NFATC1 →	+1.433	+3.082	<.001	.007	3	1
LARGE_INTESTINE	IL20 →	+0.196	+3.247	<.001	.001	3	1
LARGE_INTESTINE	SMIM33 →	+0.607	+3.577	<.001	.002	3	1
LARGE_INTESTINE	WSCD2 →	+0.098	+2.648	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PLA2G3 by MC5R expression — LARGE_INTESTINE

Explore this box plot interactively →