MC4R

Across TCGA pan-cancer cohorts, MC4R Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MC4R data layer compared with 20 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher MC4R Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated MC4R expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

BRCA, DLBC, and SKCM are the cancer types where MC4R Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.583	0.924	<.001	34	view →
DLBC	OS	Median	All	0.053	0.936	<.001	12	view →
SKCM	OS	Median	III,IV	0.072	0.802	<.001	8	view →
SARC	DFS	Median	All	0.094	0.632	<.001	6	view →
PRAD	OS	Median	All	0.579	0.883	<.001	6	view →
UCEC	DFS	Median	All	0.910	0.621	.031	4	view →
HNSC	DFS	Median	III,IV	1.000	0.288	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MC4R–BRCA (OS)

Open the BRCA breakdown →