MC3R

Across TCGA patient cohorts, MC3R RNA expression is significantly associated with the go_rna of many other GO terms, with 6,268 significant associations in total. STAD shows the largest number of these associations.

The most reproducible MC3R-associated GO terms across cancer lineages are Regulation of axonogenesis, Negative regulation of developmental growth, and Positive regulation of neurogenesis. Each is linked with MC3R in more than 10 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of axonogenesis grouped by MC3R-low versus MC3R-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of axonogenesis →	+0.041	+0.072	<.001	<.001	3	11
STAD	Negative regulation of developmental growth →	+0.042	+0.081	<.001	<.001	3	10
ESCA	Positive regulation of neurogenesis →	+0.043	+0.102	<.001	.002	3	10
STAD	Axon guidance →	+0.029	+0.066	<.001	<.001	3	10
STAD	Sensory organ morphogenesis →	+0.031	+0.074	<.001	<.001	3	9
STAD	Negative regulation of axonogenesis →	+0.044	+0.081	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,268 associations by consensus.

Regulation of axonogenesis by MC3R expression — STAD

Explore this box plot interactively →