MC3R

Across TCGA pan-cancer cohorts, MC3R RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated MC3R data layer compared with 5 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher MC3R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MC3R expression acts as an unfavorable survival marker, although some lineages such as ACC and MESO show a favorable association.

BLCA, KIRC, and STAD are the cancer types where MC3R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.109	0.352	<.001	135	view →
KIRC	DFS	Tertile	All	0.603	0.813	.002	66	view →
STAD	OS	Tertile	IV	0.134	0.610	.001	58	view →
DLBC	OS	Tertile	III,IV	0.154	0.735	.010	52	view →
SARC	OS	Tertile	All	0.564	0.852	<.001	42	view →
LIHC	OS	Tertile	All	0.365	0.726	<.001	39	view →
LUAD	DFS	Tertile	IV	0.109	0.714	.001	36	view →
HNSC	OS	Tertile	III,IV	0.635	0.740	.012	21	view →
TGCT	DFS	Tertile	II,III,IV	0.621	0.949	.034	18	view →
GBM	DFS	Tertile	All	0.169	0.330	.026	15	view →
KIRP	DFS	Tertile	All	0.531	0.806	.042	12	view →
ACC	OS	Tertile	All	0.887	0.523	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

MC3R–BLCA (DFS)

Open the BLCA breakdown →