MC3R

Across TCGA patient cohorts, MC3R protein abundance is significantly associated with the RNA expression of many other genes, with 65 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MC3R-associated genes across cancer lineages are PI4KB, HPS6, and CHP2. Each is linked with MC3R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MC3R versus PI4KB in GBM, with a Pearson correlation of -0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PI4KB →	-0.432	-0.683	.001	.006	3	1
GBM	HPS6 →	+0.500	+0.676	.008	<.001	3	1
GBM	CHP2 →	+0.125	+0.789	.002	.007	3	1
GBM	NUDT4B →	+0.133	+0.769	.002	.003	3	1
GBM	RNA5SP430 →	+1.482	+0.785	.004	.007	3	1
GBM	CST9LP2 →	+0.610	+0.769	.006	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

MC3R vs PI4KB — GBM

Explore this scatter interactively →