MC3R

Across TCGA patient cohorts, MC3R mutation is significantly associated with the RNA expression of many other genes, with 3,073 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC3R-associated genes across cancer lineages are CENPU, FAM168B, and SPC25. Each is linked with MC3R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPU grouped by MC3R-low versus MC3R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CENPU →	+0.740	+2.032	<.001	.001	3	3
UCEC	FAM168B →	+0.534	+2.423	.001	.001	3	3
UCEC	SPC25 →	+0.639	+3.711	.002	<.001	3	3
UCEC	CCNB2 →	+0.848	+3.523	<.001	<.001	3	3
UCEC	SLBP →	+0.567	+3.119	<.001	<.001	3	3
UCEC	CPSF2 →	+0.449	+2.021	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,073 associations by consensus.

CENPU by MC3R expression — UCEC

Explore this box plot interactively →