MC3R

Across TCGA patient cohorts, MC3R mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC3R-associated genes across cancer lineages are eEF2, A-Raf_pS299, and ERK2. Each is linked with MC3R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by MC3R-low versus MC3R-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.383	+2.459	.004	.018	3	2
UCEC	A-Raf_pS299 →	-0.109	-1.415	.014	.046	3	2
UCEC	ERK2 →	+0.211	+1.415	.003	.046	3	2
UCEC	GAPDH →	+0.460	+2.459	.022	.018	3	2
UCEC	GSK-3_pS9 →	-0.541	-2.222	<.001	.009	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.540	+2.594	.004	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

eEF2 by MC3R expression — UCEC

Explore this box plot interactively →