MC3R

Across TCGA cell cohorts, MC3R RNA expression is significantly associated with the go_rna of many other GO terms, with 306 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MC3R-associated GO terms across cancer lineages are Positive regulation of proteolysis, Response to interleukin-6, and TRAIL-activated apoptotic signaling pathway. Each is linked with MC3R in more than 2 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of proteolysis grouped by MC3R-low versus MC3R-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Positive regulation of proteolysis →	+0.103	+0.050	<.001	.006	3	3
BLOOD_Lymphoma	Response to interleukin-6 →	+0.094	+0.050	.001	.006	3	2
LUNG_NSCLC_LUAD	TRAIL-activated apoptotic signaling pathway →	+0.114	+0.029	.006	.008	3	2
BLOOD_Lymphoma	Chordate pharynx development →	+1.333	+0.048	<.001	.008	3	2
BLOOD_Lymphoma	Negative regulation of leukocyte differentiation →	+0.103	+0.050	<.001	.006	3	2
BLOOD_Lymphoma	Negative regulation of hemopoiesis →	+0.105	+0.050	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 306 associations by consensus.

Positive regulation of proteolysis by MC3R expression — BLOOD_Lymphoma

Explore this box plot interactively →