MC3R

Across TCGA cell cohorts, MC3R mutation is significantly associated with the RNA expression of many other genes, with 147 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MC3R-associated genes across cancer lineages are TTLL12, SH3GL2, and GTF2H3. Each is linked with MC3R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC3R-to-partner and partner-to-MC3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTLL12 grouped by MC3R-low versus MC3R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC3R→partner) and Y-score (partner→MC3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL12 →	+0.850	+3.299	.002	.004	3	1
LARGE_INTESTINE	SH3GL2 →	+0.993	+3.474	.006	.003	3	1
LARGE_INTESTINE	GTF2H3 →	+0.808	+3.299	<.001	.004	3	1
LARGE_INTESTINE	RFPL2 →	+0.133	+3.212	.006	.006	3	1
LARGE_INTESTINE	CNMD →	+0.022	+2.353	<.001	.008	3	1
LARGE_INTESTINE	WDR61 →	+0.409	+3.237	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 147 associations by consensus.

TTLL12 by MC3R expression — LARGE_INTESTINE

Explore this box plot interactively →