MC1R

Across TCGA patient cohorts, MC1R mutation is significantly associated with the RNA expression of many other genes, with 3,244 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MC1R-associated genes across cancer lineages are MIR4735, TMEM31, and ERCC6L. Each is linked with MC1R in more than 1 cancer types. Because this analysis shows association rather than direction, both MC1R-to-partner and partner-to-MC1R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4735 grouped by MC1R-low versus MC1R-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MC1R→partner) and Y-score (partner→MC1R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	MIR4735 →	+0.509	+5.355	<.001	.005	3	2
UCEC	TMEM31 →	-0.489	-1.820	.009	.003	3	2
UCEC	ERCC6L →	+0.445	+2.016	.009	.005	3	2
UCEC	TSPYL1 →	+0.500	+2.724	.001	.003	3	2
UCEC	FAM53B →	+0.454	+1.885	<.001	.001	3	2
UCEC	ZNF398 →	+0.427	+2.584	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,244 associations by consensus.

MIR4735 by MC1R expression — LIHC

Explore this box plot interactively →