MBTD1

Across TCGA pan-cancer cohorts, MBTD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MBTD1 data layer compared with 29 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MBTD1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MBTD1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and GBM are the cancer types where MBTD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.898	.003	26	view →
LUAD	OS	Quartile	II,III,IV	0.918	0.508	.015	8	view →
GBM	OS	Quartile	All	0.671	1.000	.033	2	view →
CCRCC	OS	Median	II,III,IV	0.511	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MBTD1–LSCC (DFS)

Open the LSCC breakdown →