MBTD1

Across TCGA patient cohorts, MBTD1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBTD1-associated genes across cancer lineages are TFRC, Notch1, and p21. Each is linked with MBTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTD1-to-partner and partner-to-MBTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by MBTD1-low versus MBTD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTD1→partner) and Y-score (partner→MBTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.617	+3.321	.026	.010	3	2
UCEC	Notch1 →	+0.302	+3.321	<.001	.010	3	1
UCEC	p21 →	+0.304	+3.321	.002	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.611	-3.000	.009	.036	3	1
UCEC	p90 RSK_pT359_S363 →	-0.223	-2.990	.035	.036	3	1
UCEC	PDCD4 →	-0.845	-3.321	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

TFRC by MBTD1 expression — UCEC

Explore this box plot interactively →