MBTD1

Across TCGA cell cohorts, MBTD1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBTD1-associated genes across cancer lineages are KLHL40, C10orf53, and NEXMIF. Each is linked with MBTD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBTD1-to-partner and partner-to-MBTD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLHL40 grouped by MBTD1-low versus MBTD1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBTD1→partner) and Y-score (partner→MBTD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1
LARGE_INTESTINE	TKTL2 →	+0.052	+3.187	<.001	.006	2	1
LARGE_INTESTINE	NAA11 →	+0.412	+3.443	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

KLHL40 by MBTD1 expression — BLOOD_Lymphoma

Explore this box plot interactively →