MBOAT7

Across TCGA pan-cancer cohorts, MBOAT7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated MBOAT7 data layer compared with 19 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher MBOAT7 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MBOAT7 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

CCRCC, PDAC, and UCEC are the cancer types where MBOAT7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.744	0.978	.003	51	view →
PDAC	OS	Quartile	All	0.383	0.722	.002	21	view →
UCEC	DFS	Median	All	0.840	0.969	.005	12	view →
GBM	DFS	Quartile	All	0.251	0.535	.018	6	view →
LUAD	DFS	Median	II,III,IV	0.935	0.736	.015	6	view →
HNSC	OS	Median	II,III,IV	1.000	0.954	.023	3	view →
LSCC	OS	Quartile	II,III,IV	0.779	0.938	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

MBOAT7–CCRCC (OS)

Open the CCRCC breakdown →