MBOAT7

Across TCGA cell cohorts, MBOAT7 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBOAT7-associated genes across cancer lineages are CCR8, XAGE5, and CRYAA. Each is linked with MBOAT7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBOAT7-to-partner and partner-to-MBOAT7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by MBOAT7-low versus MBOAT7-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBOAT7→partner) and Y-score (partner→MBOAT7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
OVARY	XAGE5 →	+0.255	+5.196	<.001	.005	3	1
BLOOD_Leukemia	CRYAA →	+0.049	+4.705	.006	.003	3	1
BLOOD_Leukemia	OR10T2 →	+0.584	+4.276	.005	.007	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	GHRH →	+0.080	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

CCR8 by MBOAT7 expression — SOFT_TISSUE

Explore this box plot interactively →