MBOAT4

Across TCGA patient cohorts, MBOAT4 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBOAT4-associated genes across cancer lineages are EGFR_pY1068, 14-3-3_beta, and eIF4E. Each is linked with MBOAT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBOAT4-to-partner and partner-to-MBOAT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by MBOAT4-low versus MBOAT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBOAT4→partner) and Y-score (partner→MBOAT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.223	-2.459	.023	.018	3	2
UCEC	14-3-3_beta →	-0.102	-3.432	.009	.005	3	1
UCEC	eIF4E →	+0.237	+3.335	.004	.005	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.584	.003	.002	3	1
UCEC	ERK2 →	+0.233	+2.700	.002	.006	3	1
UCEC	JNK2 →	+0.303	+3.486	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

EGFR_pY1068 by MBOAT4 expression — UCEC

Explore this box plot interactively →