MBOAT4

Across TCGA pan-cancer cohorts, MBOAT4 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MBOAT4 data layer compared with 3 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher MBOAT4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MBOAT4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

STAD, SKCM, and LIHC are the cancer types where MBOAT4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	III,IV	0.234	0.478	<.001	126	view →
SKCM	OS	Tertile	All	0.917	0.806	<.001	76	view →
LIHC	OS	Quartile	III,IV	0.314	0.695	<.001	57	view →
KIRP	DFS	Median	All	0.870	0.943	.012	46	view →
HNSC	DFS	Median	IV	0.433	0.225	.006	45	view →
LGG	DFS	Quartile	All	0.294	0.497	.004	19	view →
THCA	DFS	Median	II,III,IV	0.849	0.273	.016	14	view →
ESCA	OS	Tertile	All	0.552	0.729	.020	13	view →
LUSC	OS	Quartile	II,III,IV	0.263	0.602	<.001	11	view →
BRCA	DFS	Median	II,III,IV	0.927	0.955	.012	10	view →
THYM	OS	Median	II,III,IV	0.941	0.596	.007	6	view →
BLCA	DFS	Quartile	All	0.304	0.595	.032	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MBOAT4–STAD (DFS)

Open the STAD breakdown →