MBNL1

Across TCGA cell cohorts, MBNL1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MBNL1-associated genes across cancer lineages are WDR87, TMPRSS12, and EPPIN. Each is linked with MBNL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBNL1-to-partner and partner-to-MBNL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR87 grouped by MBNL1-low versus MBNL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBNL1→partner) and Y-score (partner→MBNL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	WDR87 →	+0.028	+4.095	<.001	.009	3	1
SKIN	TMPRSS12 →	+0.063	+4.930	<.001	.001	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	ACTRT1 →	+0.035	+5.201	<.001	.006	3	1
BLOOD_Leukemia	GH2 →	+0.029	+5.969	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

WDR87 by MBNL1 expression — SKIN

Explore this box plot interactively →