MBNL1-AS1

Across TCGA pan-cancer cohorts, MBNL1-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated MBNL1-AS1 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MBNL1-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated MBNL1-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and HNSC are the cancer types where MBNL1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Tertile	All	0.851	0.725	<.001	86	view →
KIRC	OS	Tertile	All	0.727	0.554	<.001	81	view →
HNSC	DFS	Tertile	III,IV	0.747	0.552	<.001	50	view →
LGG	OS	Median	All	0.928	0.860	<.001	40	view →
OV	OS	Median	III,IV	0.733	0.634	.003	26	view →
THCA	OS	Tertile	II,III,IV	0.947	1.000	.005	23	view →
LAML	DFS	Quartile	All	0.622	0.226	.001	22	view →
KICH	DFS	Tertile	All	0.645	1.000	.016	15	view →
LUSC	OS	Quartile	All	0.818	0.666	.001	14	view →
UVM	OS	Tertile	All	0.829	0.508	.015	12	view →
CHOL	DFS	Quartile	All	0.798	0.116	.006	12	view →
LIHC	OS	Tertile	II,III,IV	0.899	0.640	.007	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

MBNL1-AS1–SKCM (OS)

Open the SKCM breakdown →