MBNL1-AS1

Across TCGA pan-cancer cohorts, MBNL1-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MBNL1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MBNL1-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types MBNL1-AS1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where MBNL1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MBNL1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−4.477	<.001	11	view →
COAD	Male	II,III,IV	−1.874	<.001	11	view →
LUAD	Male	III,IV	−1.551	<.001	11	view →
THCA	Male	III,IV	−0.777	<.001	11	view →
KICH	Female	All	−0.793	<.001	10	view →
READ	All	All	−2.358	<.001	7	view →
LUSC	Male	III,IV	−1.765	<.001	7	view →
UCEC	All	All	−2.381	<.001	6	view →
BRCA	All	III,IV	−1.326	<.001	6	view →
STAD	All	All	−1.198	.002	4	view →
PAAD	All	All	−0.384	.015	4	view →
LIHC	All	All	+0.106	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MBNL1-AS1–BLCA

Open the BLCA breakdown →