MBL2

Across TCGA patient cohorts, MBL2 mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible MBL2-associated genes across cancer lineages are YB-1_pS102, YAP_pS127, and Rb_pS807_S811. Each is linked with MBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBL2-to-partner and partner-to-MBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YB-1_pS102 grouped by MBL2-low versus MBL2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBL2→partner) and Y-score (partner→MBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	YB-1_pS102 →	+0.283	+2.871	<.001	.033	2	1
SKCM	YAP_pS127 →	-0.656	-3.169	<.001	.018	2	1
LUSC	Rb_pS807_S811 →	+0.645	+2.816	.007	.036	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

YB-1_pS102 by MBL2 expression — LUSC

Explore this box plot interactively →