MBL2

Across TCGA cell cohorts, MBL2 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBL2-associated genes across cancer lineages are PTCHD1, ASPN, and RASGEF1C. Each is linked with MBL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBL2-to-partner and partner-to-MBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTCHD1 grouped by MBL2-low versus MBL2-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBL2→partner) and Y-score (partner→MBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PTCHD1 →	+0.075	+4.191	<.001	.007	3	2
LARGE_INTESTINE	ASPN →	+0.037	+3.426	.004	.007	3	1
LARGE_INTESTINE	RASGEF1C →	+0.223	+3.333	.005	.009	3	1
LARGE_INTESTINE	OR2W3 →	+0.861	+3.355	.002	.007	3	1
LUNG_SCLC	OPN1LW →	+0.150	+5.029	<.001	.006	3	1
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PTCHD1 by MBL2 expression — BLOOD_Lymphoma

Explore this box plot interactively →