MBL2

Across TCGA cell cohorts, MBL2 mutation is significantly associated with the mutation status of many other genes, with 3,044 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBL2-associated genes across cancer lineages are POT1, JAKMIP1, and COQ3. Each is linked with MBL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MBL2-to-partner and partner-to-MBL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POT1 grouped by MBL2-low versus MBL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBL2→partner) and Y-score (partner→MBL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	POT1 →	+2.630	+3.047	.005	.005	1	3
LARGE_INTESTINE	JAKMIP1 →	+2.340	+4.278	<.001	<.001	1	3
SKIN	COQ3 →	+4.239	+5.053	.007	.007	1	3
LARGE_INTESTINE	MYO1A →	+2.215	+4.169	<.001	<.001	1	3
LARGE_INTESTINE	GPR162 →	+3.799	+3.329	.005	.005	1	3
SKIN	ENTPD2 →	+5.824	+5.824	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,044 associations by consensus.

POT1 by MBL2 expression — LARGE_INTESTINE

Explore this box plot interactively →