MBD6

Across TCGA cell cohorts, MBD6 mutation is significantly associated with the RNA expression of many other genes, with 927 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MBD6-associated genes across cancer lineages are LEUTX, BMPR1A, and BCL7A. Each is linked with MBD6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD6-to-partner and partner-to-MBD6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LEUTX grouped by MBD6-low versus MBD6-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD6→partner) and Y-score (partner→MBD6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LEUTX →	+0.245	+5.196	<.001	.005	3	2
LARGE_INTESTINE	BMPR1A →	+0.743	+3.257	<.001	.002	3	2
LARGE_INTESTINE	BCL7A →	+0.708	+3.169	.003	.009	3	2
LARGE_INTESTINE	GPR63 →	+1.019	+3.459	<.001	<.001	3	2
LARGE_INTESTINE	ARL6 →	+0.542	+2.043	<.001	.008	3	2
LARGE_INTESTINE	PLCD4 →	+0.416	+2.459	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 927 associations by consensus.

LEUTX by MBD6 expression — OVARY

Explore this box plot interactively →