Across TCGA patient cohorts, MBD5 protein abundance is significantly associated with the RNA expression of many other genes, with 89 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible MBD5-associated genes across cancer lineages are NECAB2, BET1, and KLHL29. Each is linked with MBD5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD5-to-partner and partner-to-MBD5 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD5→partner) and Y-score (partner→MBD5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NECAB2 →	+0.750	+1.225	.001	.004	3	1
BRCA	BET1 →	-0.475	-0.865	.009	.009	3	1
BRCA	KLHL29 →	+0.744	+1.578	<.001	.004	3	1
BRCA	ITIH5 →	+1.462	+0.903	<.001	.004	3	1
BRCA	AVPR2 →	+0.834	+0.903	.001	.004	3	1
BRCA	USHBP1 →	+0.778	+0.910	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 89 associations by consensus.

Exploration

MBD5 survival (RNA) · tumor vs normal (RNA) · all MBD5 data types