MBD3L1

Across TCGA patient cohorts, MBD3L1 mutation is significantly associated with the RNA expression of many other genes, with 773 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD3L1-associated genes across cancer lineages are USP9YP5, LINC02620, and HPS1. Each is linked with MBD3L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD3L1-to-partner and partner-to-MBD3L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP9YP5 grouped by MBD3L1-low versus MBD3L1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD3L1→partner) and Y-score (partner→MBD3L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	USP9YP5 →	+0.084	+8.471	<.001	.005	3	2
COAD	LINC02620 →	+0.300	+3.754	<.001	.008	3	2
SKCM	HPS1 →	+0.587	+3.478	.004	.002	3	2
LUSC	SNRPGP7 →	+0.358	+5.474	<.001	.005	3	2
BRCA	MIR525 →	+0.461	+7.731	<.001	.009	3	1
BRCA	RNY4P30 →	+0.429	+9.057	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 773 associations by consensus.

USP9YP5 by MBD3L1 expression — BRCA

Explore this box plot interactively →