MBD2

Across TCGA patient cohorts, MBD2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,505 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MBD2-associated genes across cancer lineages are CXXC1, NARS1, and NALCN. Each is linked with MBD2 in more than 6 cancer types. Because this analysis shows association rather than direction, both MBD2-to-partner and partner-to-MBD2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MBD2 versus CXXC1 in BRCA, with a Pearson correlation of 0.35.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD2→partner) and Y-score (partner→MBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CXXC1 →	+0.651	+0.171	<.001	.002	3	7
HNSC	NARS1 →	+0.616	+0.191	<.001	<.001	3	6
GBM	NALCN →	-0.829	-0.193	.002	.005	3	5
LSCC	RELCH →	+0.543	+0.222	<.001	<.001	3	5
LSCC	MBD1 →	+0.401	+0.194	<.001	<.001	3	5
BRCA	SKA1 →	+0.851	+0.187	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,505 associations by consensus.

MBD2 vs CXXC1 — BRCA

Explore this scatter interactively →