MBD2

Across TCGA patient cohorts, MBD2 mutation is significantly associated with the RNA expression of many other genes, with 3,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD2-associated genes across cancer lineages are CHEK2P3, KCNAB1-AS1, and RPL23AP4. Each is linked with MBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD2-to-partner and partner-to-MBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHEK2P3 grouped by MBD2-low versus MBD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD2→partner) and Y-score (partner→MBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CHEK2P3 →	+0.157	+4.444	<.001	.006	3	2
LUAD	KCNAB1-AS1 →	+0.109	+3.613	<.001	.006	3	2
READ	RPL23AP4 →	+0.171	+5.039	<.001	.008	3	2
UCEC	BNIP3P41 →	+0.011	+4.156	<.001	.004	3	2
SKCM	VDAC2P4 →	+0.084	+4.661	<.001	.004	3	1
SKCM	LINC00700 →	+0.068	+4.381	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,133 associations by consensus.

CHEK2P3 by MBD2 expression — LUAD

Explore this box plot interactively →