MBD2

Across TCGA patient cohorts, MBD2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MBD2-associated genes across cancer lineages are FoxM1, STAT3_pY705, and Stathmin. Each is linked with MBD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MBD2-to-partner and partner-to-MBD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MBD2-low versus MBD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MBD2→partner) and Y-score (partner→MBD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.290	+3.087	.005	<.001	3	2
UCEC	STAT3_pY705 →	-0.522	-1.906	<.001	.014	3	2
UCEC	Stathmin →	+0.151	+3.348	.006	.004	3	2
UCEC	EGFR →	-0.213	-3.143	<.001	.018	3	1
UCEC	eIF4G →	+0.357	+2.115	.004	.017	3	1
UCEC	A-Raf_pS299 →	-0.117	-2.000	.015	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

FoxM1 by MBD2 expression — UCEC

Explore this box plot interactively →