MB21D2

Across TCGA patient cohorts, MB21D2 mutation is significantly associated with the RNA expression of many other genes, with 2,934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MB21D2-associated genes across cancer lineages are MIR6865, USP8, and ARHGEF38-IT1. Each is linked with MB21D2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MB21D2-to-partner and partner-to-MB21D2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6865 grouped by MB21D2-low versus MB21D2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MB21D2→partner) and Y-score (partner→MB21D2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6865 →	+0.383	+1.318	.004	.004	3	3
UCEC	USP8 →	+0.413	+2.169	<.001	<.001	3	3
CESC	ARHGEF38-IT1 →	+0.676	+3.663	<.001	.007	3	2
READ	TRAJ6 →	+0.878	+4.202	<.001	.008	3	2
READ	MAPK6P6 →	+0.095	+4.280	<.001	.007	3	2
READ	DNAJA1P2 →	+0.175	+4.533	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,934 associations by consensus.

MIR6865 by MB21D2 expression — UCEC

Explore this box plot interactively →